Use subprocess.run:
import subprocess
subprocess.run(["ls", "-l"]) Another common way is os.system but you shouldn’t use it because it is unsafe if any parts of the command come from outside your program or can contain spaces or other special characters, also subprocess.run is generally more flexible (you can get the stdout, stderr, the “real” status code, better error handling, etc.). Even the documentation for os.system recommends using subprocess instead.
On Python 3.4 and earlier, use subprocess.call instead of .run:
subprocess.call(["ls", "-l"])